Ekspresi BMP2 dan TRAF6 pada Jaringan Periodontal setelah Pemberian Ekstrak Kopi Robusta selama Pergerakan Gigi Ortodonti

Orthodontic tooth movement occurs due to mechanical stimulation followed by alveolar bone and periodontal ligament remodeling. Bone remodeling is the process of resorption in areas tension formation tension. Various techniques drugs are used speed up orthodontic treatment. This study aims analyze expression BMP2 TRAP6 on after administration Robusta coffee extract. Twenty-four Wistar rats were divided into 4 groups: C1 (2 weeks) C2 (3 given force (OMF) T1 T2 groups OMF was performed moving maxillary right permanent molars mesially with a Niti closed coil spring. Observations made 15th 22nd day immunohistochemical examination determine TRAP6. Administration extract for 2 weeks 3 increased (p <0.05). during movement.